Biochemical recurrence is a clinical situation experienced by 20 to 40% of prostate cancer patients treated with radical prostatectomy (RP).Prostate bed Gastro-Intestinal Tract Support (PB) radiation therapy (RT) remains the mainstay salvage treatment, although it remains non-curative for up to 30% of patients developing further recurrence.Positron
Biomedical Research and Informatics Living Laboratory for Innovative Advances of New Technologies in Community Mobility Rehabilitation: Protocol for Evaluation and Rehabilitation of Mobility Across Continuums of Care
BackgroundRapid advances in technologies over the past 10 years have enabled large-scale biomedical and Gastro-Intestinal Tract Support psychosocial rehabilitation research to improve the function and social integration of persons with physical impairments across the lifespan.The Biomedical Research and Informatics Living Laboratory for Innovative
Potassium KCa3.1 channel overexpression deteriorates functionality and availability of channels at the outer cellular membrane
Abstract The engineered expression of K+ channels has been proposed as a potential treatment for epilepsy due to their exceptional ability to hyperpolarize neurons.A number of rodent Hockey Protective - Helmet - Combo models of gene therapy have yielded promising outcomes.However, the prevailing viral delivery methods for transgenes lack external c
Influence of Gall-Inducing Insects (Cynipini) on the Nutritional and Defensive Chemical Profile of Quercus rugosa
Analyzing the nutritional and defensive chemistry of Quercus rugosa provides insight into gall wasp interactions.Quercus rugosa is the most widely distributed white oak species in Mexico.It is the dominant canopy species in its geographic distribution range and MEN 50+ MULTIVITAMINS has the largest number of associated gall wasp species (Cynipidae:
Combining EZH2 and HDAC inhibitors to target castration-resistant prostate cancers
Development of resistance in castration-resistant prostate cancer (CRPC) involves epigenetic pathways.A new study in PLOS Biology demonstrates 510 that combined therapy targeting enhancer of zeste homolog 2 (EZH2) and histone deacetylases (HDACs) may sensitize CRPC to both epigenetic and standard therapies.Development of resistance in castration-re